It is a substrate for the glutathione production - which can give us more glutathione and more neutralizing possibilities,.What is NAC for Tylenol overdose? It works in two ways: That's why the main consequence of paracetamol overdose is liver failure. Being unable to neutralize all the deadly NAPQI molecules, we're prone to its damaging properties. Here comes the problem, as we only have limited glutathione storage. When there is too much acetaminophen, more substance follows the oxidation pathway, producing more toxic NAPQI. NAPQI is conjugated and excreted with urine.
Luckily, we have a mechanism for neutralizing NAPQI using a glutathione molecule. It can cause liver necrosis (death of the liver cells). Oxidation leads to the production of a small amount of a toxic metabolite, NAPQI (N-acetyl-p-benzoquinoneimine). Most of the paracetamol breakdown happens with the process of conjugation (95% of it). When you take Tylenol in regular, therapeutic doses, the substance is processed by two mechanisms.
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